Issue 78, 2014
From the journal:

Chemical Communications

An octadentate bifunctional chelating agent for the development of stable zirconium-89 based molecular imaging probes†

Malay Patra,‡a   Andreas Bauman,‡b   Cristina Mari,a   Christiane A. Fischer,b   Olivier Blacque,a   Daniel Häussinger,c   Gilles Gasser*a  and  Thomas L. Mindt*b  

* Corresponding authors

a Department of Chemistry, University of Zurich, Winterthurerstrasse 190, CH-8057 Zurich, Switzerland
E-mail: gilles.gasser@chem.uzh.ch
Fax: +41 44 635 68 03

b Division of Radiopharmaceutical Chemistry, Clinic of Radiology and Nuclear Medicine, University of Basel Hospital, Petersgraben 4, CH-4031 Basel, Switzerland
E-mail: Thomas.Mindt@usb.ch
Fax: +41 61 265 55 59

c Department of Chemistry, University of Basel, St. Johanns-Ring 19, CH-4056 Basel, Switzerland

Abstract

89Zr-based imaging agents hold great promise as novel radio-tracers in nuclear medicine. However, insufficient stability of currently used radiometal complexes in vivo is a safety concern for clinical applications. We herein report the first octadentate bifunctional chelating agent for the development of 89Zr-labelled (bio)conjugates with improved stability.

Graphical abstract: An octadentate bifunctional chelating agent for the development of stable zirconium-89 based molecular imaging probes

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Article information

DOI
https://doi.org/10.1039/C4CC05558F
Article type
Communication
Submitted
18 Jul 2014
Accepted
13 Aug 2014
First published
13 Aug 2014

Chem. Commun., 2014,50, 11523-11525

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An octadentate bifunctional chelating agent for the development of stable zirconium-89 based molecular imaging probes

M. Patra, A. Bauman, C. Mari, C. A. Fischer, O. Blacque, D. Häussinger, G. Gasser and T. L. Mindt, Chem. Commun., 2014, 50, 11523 DOI: 10.1039/C4CC05558F

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