Issue 38, 2014

A concise [C+NC+CC] coupling-enabled synthesis of kaitocephalin

Abstract

A 15-step synthesis of the iGluR antagonist kaitocephalin from aspartic acid is reported. The linchpin pyrrolidine ring of the target molecule is efficiently assembled with in a single operation via an asymmetric [C+NC+CC] reaction.

Graphical abstract: A concise [C+NC+CC] coupling-enabled synthesis of kaitocephalin

Supplementary files

Article information

Article type
Communication
Submitted
06 Mar 2014
Accepted
27 Mar 2014
First published
02 Apr 2014

Chem. Commun., 2014,50, 4908-4910

Author version available

A concise [C+NC+CC] coupling-enabled synthesis of kaitocephalin

P. Garner, L. Weerasinghe, I. Van Houten and J. Hu, Chem. Commun., 2014, 50, 4908 DOI: 10.1039/C4CC01692K

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