Issue 4, 2015
From the journal:

Analyst

A turn-on fluorescent probe for hypochlorous acid based on the oxidation of diphenyl telluride†

Parthiban Venkatesana  and  Shu-Pao Wu ORCID logo *a  

* Corresponding authors

a Department of Applied Chemistry, National Chiao Tung University, Hsinchu, Taiwan 300, Republic of China
E-mail: spwu@mail.nctu.edu.tw
Tel: +886-3-5712121, ext. 56506

Abstract

A fluorescent probe HCTe was developed for rapid detection of hypochlorous acid based on the specific HOCl-promoted oxidation of diphenyl telluride. The reaction is accompanied by an 82-fold increase in the fluorescence quantum yield (from 0.009 to 0.75). The fluorescence turn-on mechanism is achieved by the suppression of photoinduced electron transfer (PET) from the diphenyl telluride group to BODIPY. The fluorescence intensity of the reaction between HOCl and HCTe is linear in the HOCl concentration range of 1 to 10 μM with a detection limit of 41.3 nM (S/N = 3). In addition, confocal fluorescence microscopy imaging using RAW264.7 macrophages demonstrated that HCTe could be an efficient fluorescent probe for HOCl detection in living cells.

Graphical abstract: A turn-on fluorescent probe for hypochlorous acid based on the oxidation of diphenyl telluride

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Article information

DOI
https://doi.org/10.1039/C4AN02116A
Article type
Paper
Submitted
18 Nov 2014
Accepted
21 Dec 2014
First published
24 Dec 2014

Analyst, 2015,140, 1349-1355

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A turn-on fluorescent probe for hypochlorous acid based on the oxidation of diphenyl telluride

P. Venkatesan and S. Wu, Analyst, 2015, 140, 1349 DOI: 10.1039/C4AN02116A

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