Issue 40, 2013
From the journal:

RSC Advances

The regioselective Larock indole synthesis catalyzed by NHC–palladium complexes†

Pan He,a   Yufeng Du,a   Gang Liu,a   Changsheng Cao,*a   Yanhui Shi,*ab   Juan Zhanga  and  Guangsheng Pangc  

* Corresponding authors

a School of Chemistry and Chemical Engineering and Jiangsu Key Laboratory of Green Synthetic Chemistry for Functional Materials, Jiangsu Normal University, Xuzhou, Jiangsu 221116, P. R. China
E-mail: yhshi@jsnu.edu.cn
Tel: +86 516 8350 0349

b State Key Laboratory of Coordination Chemistry, Nanjing University, Nanjing, Jiangsu 210093, P. R. China

c State Key Laboratory of Inorganic Synthesis and Preparative Chemistry, Jilin University, Changchun, Jilin 130012, P. R. China

Abstract

The first practical and regioselective process for the synthesis of 2,3-disubstituted indoles from the reaction of o-iodoanilines or o-bromoanilines and their derivatives with symmetrical and unsymmetrical internal alkynes catalyzed by a ferrocene-functionalized N-heterocyclic carbene (NHC)–palladium complex has been developed, and the indoles were isolated in good yields with high regioselectivity.

Graphical abstract: The regioselective Larock indole synthesis catalyzed by NHC–palladium complexes

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Article information

DOI
https://doi.org/10.1039/C3RA42788A
Article type
Paper
Submitted
05 Jun 2013
Accepted
29 Jul 2013
First published
30 Jul 2013

RSC Adv., 2013,3, 18345-18350

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The regioselective Larock indole synthesis catalyzed by NHC–palladium complexes

P. He, Y. Du, G. Liu, C. Cao, Y. Shi, J. Zhang and G. Pang, RSC Adv., 2013, 3, 18345 DOI: 10.1039/C3RA42788A

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