Issue 30, 2013
From the journal:

Organic & Biomolecular Chemistry

Passive fructose transporters in disease: a molecular overview of their structural specificity

D. Tyler McQuade,†*ab   Matthew B. Plutschack†ab  and  Peter H. Seebergerb  

* Corresponding authors

a Department of Chemistry and Biochemistry, Florida State University, Tallahassee, FL 32306, USA
E-mail: mcquade@chem.fsu.edu

b Max Planck Institute of Colloids and Interfaces Am Mühlenberg 1, 14476 Potsdam, Germany
E-mail: tyler.mcquade@mpikg.mpg.de

Abstract

The SLC2 family of facilitative Glucose transporters (Gluts) contains 14 isoforms divided into three classes based on amino acid sequence. While the majority of these proteins transport glucose, a subset can transport fructose. Recently, fructose and the Gluts responsible for fructose uptake have received increased interest due to the correlation between high fructose consumption and early onset of metabolic syndrome. In addition, the up-regulation of Gluts in certain cancers has made possible the development of a number of fructose probes for imaging cancer. Although structure activity data has defined some aspects of fructose-specific uptake, a far more detailed clarification of the variables governing the onset and progression of fructose-correlated diseases is still needed. Here, we summarize what is known about molecular structure and fructose uptake as it relates to the correlation of fructose and disease.

Graphical abstract: Passive fructose transporters in disease: a molecular overview of their structural specificity

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Article information

DOI
https://doi.org/10.1039/C3OB40805A
Article type
Perspective
Submitted
22 Apr 2013
Accepted
10 Jun 2013
First published
20 Jun 2013

Org. Biomol. Chem., 2013,11, 4909-4920

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Passive fructose transporters in disease: a molecular overview of their structural specificity

D. T. McQuade, M. B. Plutschack and P. H. Seeberger, Org. Biomol. Chem., 2013, 11, 4909 DOI: 10.1039/C3OB40805A

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