Issue 15, 2013

Asymmetric synthesis of cyclo-archaeol and β-glucosyl cyclo-archaeol

Abstract

An efficient asymmetric synthesis of cyclo-archaeol and β-glucosyl cyclo-archaeol is presented employing catalytic asymmetric conjugate addition and catalytic epoxide ring opening as the key steps. Their occurrence in deep sea hydrothermal vents has been confirmed by chromatographic comparison with natural samples.

Graphical abstract: Asymmetric synthesis of cyclo-archaeol and β-glucosyl cyclo-archaeol

Supplementary files

Article information

Article type
Paper
Submitted
23 Nov 2012
Accepted
12 Feb 2013
First published
12 Feb 2013

Org. Biomol. Chem., 2013,11, 2482-2492

Asymmetric synthesis of cyclo-archaeol and β-glucosyl cyclo-archaeol

C. Ferrer, P. Fodran, S. Barroso, R. Gibson, E. C. Hopmans, J. S. Damsté, S. Schouten and A. J. Minnaard, Org. Biomol. Chem., 2013, 11, 2482 DOI: 10.1039/C3OB27277J

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