Issue 7, 2013
From the journal:

Molecular BioSystems

Molecular recognition of sulfotyrosine and phosphotyrosine by the Src homology 2 domain†

Tong Ju,a   Wei Niu,a   Ronald Cerny,a   Joshua Bollman,a   Anthony Roya  and  Jiantao Guo*a  

* Corresponding authors

a Department of Chemistry, University of Nebraska-Lincoln, Lincoln, NE, USA
E-mail: jguo4@unl.edu
Fax: +1 402 472-9402
Tel: +1 402 472-3525

Abstract

We study molecular recognition of two closely resembling posttranslational modification products, phosphotyrosine (pTyr) and sulfotyrosine (sTyr). The differences in charge, size, and binding geometry of pTyr and sTyr are the main recognition elements. Protein engineering can be applied to alter the specificity and strength of the recognition.

Graphical abstract: Molecular recognition of sulfotyrosine and phosphotyrosine by the Src homology 2 domain

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Article information

DOI
https://doi.org/10.1039/C3MB70061E
Article type
Communication
Submitted
11 Feb 2013
Accepted
26 Mar 2013
First published
26 Mar 2013

Mol. BioSyst., 2013,9, 1829-1832

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Molecular recognition of sulfotyrosine and phosphotyrosine by the Src homology 2 domain

T. Ju, W. Niu, R. Cerny, J. Bollman, A. Roy and J. Guo, Mol. BioSyst., 2013, 9, 1829 DOI: 10.1039/C3MB70061E

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