Issue 11, 2013
From the journal:

Analyst

Off-line reaction monitoring of the oxidation of alkenes in water using drop coating deposition Raman (DCDR) spectroscopy†

Shaghayegh Abdolahzadeh,a   Nicola M. Boyle,a   Apparao Draksharapu,a   Andrew C. Dennis,b   Ronald Hage,c   Johannes W. de Boerc  and  Wesley R. Browne*a  

* Corresponding authors

a Stratingh Institute for Chemistry, Faculty of Mathematics and Natural Sciences, University of Groningen, Nijenborgh 4, Groningen, The Netherlands
E-mail: w.r.browne@rug.nl
Tel: +31 50363 4428

b Andor Technology, Millenium Way, Belfast, Northern Ireland

c Catexel BV, BioPartner Center Leiden, Galileiweg 8, 2333 BD Leiden, The Netherlands

Abstract

The application of drop coating deposition Raman (DCDR) spectroscopy to the field of reaction progress monitoring is addressed in this contribution. Although, DCDR spectroscopy has seen recent application in the study of biological fluids, its application in other areas has not yet been explored. Here we apply the technique to the catalysed oxidation of alkenes to epoxides in aqueous solutions at concentrations <10 mM. The effect of surface characteristics, background interferences, homogeneity of distribution of analytes, drying time, as well as instrumental limits of detection and calibration are discussed. We demonstrate that reproducible spectra can be obtained routinely, with relatively little variance, with short acquisition times and samples volumes of 2–10 μl and as little as 1 μg of analyte. The utility of the technique compared with online reaction monitoring by 1H NMR and Raman spectroscopy is demonstrated in the excellent correlation between data obtained off and on-line.

Graphical abstract: Off-line reaction monitoring of the oxidation of alkenes in water using drop coating deposition Raman (DCDR) spectroscopy

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Article information

DOI
https://doi.org/10.1039/C3AN00330B
Article type
Paper
Submitted
16 Feb 2013
Accepted
28 Mar 2013
First published
28 Mar 2013

Analyst, 2013,138, 3163-3171

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Off-line reaction monitoring of the oxidation of alkenes in water using drop coating deposition Raman (DCDR) spectroscopy

S. Abdolahzadeh, N. M. Boyle, A. Draksharapu, A. C. Dennis, R. Hage, J. W. de Boer and W. R. Browne, Analyst, 2013, 138, 3163 DOI: 10.1039/C3AN00330B

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