SCHEDULED MAINTENANCE
One- and two-dimensional 31P NMR characterization of pure phosphate chelates in cytidine-5′-di- and -tri-phosphatoplatinum(II) complexes
Abstract
cis-Diamminedichloroplatinum(II) treated with CTP and CDP yields phosphate chelates as the major products; the chelates are diastereoisomers (Λ and Δ) formed by co-ordination through the two adjacent phosphate groups of the nucleotides, diplatinum complexes in which two nucleotide molecules bridge platinum centres through N(3) and terminal phosphate co-ordination in a ‘head-to-tail’ fashion are the minor products, these dinuclear complexes are the dominant products of the same reactions when cis-diamminediaquaplatinum(II) cation is used.
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