SCHEDULED MAINTENANCE
The imines ArC(Me)![[double bond, length half m-dash]](https://www.rsc.org/images/entities/char_e006.gif)
NCH2Ph (Ar = Ph, 2-MeO-C6H4, 4-MeO-C6H4) are hydrogenated to the corresponding secondary amines at 1000 psig H2, in 1 : 1 C6H6/MeOH, using an in situ RhI/(R)-cycphos system (cycphos = Ph2PCH(C6H11)CH2PPh2); a maximum of 91% enantiomeric excess (e.e.) is achieved at lower temperatures (–25 °C) in the presence of iodide cocatalyst.
G. Kang, W. R. Cullen, M. D. Fryzuk, B. R. James and J. P. Kutney, J. Chem. Soc., Chem. Commun., 1988, 1466 DOI: 10.1039/C39880001466
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