Issue 6, 2013
From the journal:

Journal of Materials Chemistry B

Polymeric dinulcear platinum(ii) complex micelles for enhanced antitumor activity

Rui Wang,ab   Xiuli Hu,*a   Haihua Xiao,ab   Zhigang Xie,a   Yubin Huanga  and  Xiabin Jinga  

* Corresponding authors

a State Key Laboratory of Polymer Physics and Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, 5625 renmin Street, Changchun, Jilin, China
E-mail: lily@ciac.jl.cn
Fax: +86-431-85262779
Tel: +86-431-85262779

b Graduate University of Chinese Academy of Sciences, Beijing 100049, People's Republic of China

Abstract

A dinuclear Pt(II) complex, di-DACH-Pt(II), was synthesized, characterized, and then tethered to a biodegradable and amphiphilic copolymer, and a polymer based dinuclear platinum(II) complex micelle, M(di-DACH-Pt), was prepared. The micelles showed reduced systemic toxicity and enhanced antitumor efficacy.

Graphical abstract: Polymeric dinulcear platinum(ii) complex micelles for enhanced antitumor activity

About
Cited by
Related
Download options Please wait...

Article information

DOI
https://doi.org/10.1039/C2TB00240J
Article type
Communication
Submitted
12 Oct 2012
Accepted
17 Dec 2012
First published
18 Dec 2012

J. Mater. Chem. B, 2013,1, 744-748

Permissions

Request permissions

Polymeric dinulcear platinum(II) complex micelles for enhanced antitumor activity

R. Wang, X. Hu, H. Xiao, Z. Xie, Y. Huang and X. Jing, J. Mater. Chem. B, 2013, 1, 744 DOI: 10.1039/C2TB00240J

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements