Issue 6, 2013
From the journal:

Soft Matter

Degradation of hydrolyzable hydrogel microspheres

Van Nga Nguyen,ab   Christine Vauthier,*ac   Nicolas Huang,ac   Jean-Louis Grossiord,ac   Laurence Moineac  and  Florence Agnelyac  

* Corresponding authors

a Univ Paris-Sud, Faculté de Pharmacie, 5, rue J.B. Clément, 92296 Châtenay-Malabry, Cedex, France

b Occlugel S.A.S., 12 Rue Charles de Gaulle, 78350 Jouy en Josas, France

c CNRS UMR 8612, Institut Galien Paris-Sud, 5, Rue J.B. Clément, 92296 Chatenay-Malabry, Cedex, France
E-mail: christine.vauthier@u-psud.fr
Fax: +33 146835312

Abstract

This work aims to monitor the hydrolysis of microspheres made of synthetic degradable hydrogels. Well spherical microspheres incorporating hydrolyzable crosslinkers inside their structure were first synthesized by direct suspension polymerization. Their elastic properties evaluated prior to degradation by a rheological method show that microspheres behave like nearly pure elastic material with an elastic modulus varying from 2 to 11 kPa according to their composition. The pH, swelling and rheological properties were used to follow microsphere modifications during hydrolysis. Results obtained over a period of 60 days revealed that microspheres were only partially degraded under the experimental conditions used. After this period, microspheres were highly swollen with a low elastic modulus (ranging from 0.17 to 0.83 kPa) compared to the starting material. The hydrolytic degradation rate could be tuned by modulating the crosslinking degree and the chemical structure of the degradable crosslinker included in the hydrogel network.

Graphical abstract: Degradation of hydrolyzable hydrogel microspheres

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Article information

DOI
https://doi.org/10.1039/C2SM27066H
Article type
Paper
Submitted
06 Sep 2012
Accepted
29 Nov 2012
First published
19 Dec 2012

Soft Matter, 2013,9, 1929-1936

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Degradation of hydrolyzable hydrogel microspheres

V. N. Nguyen, C. Vauthier, N. Huang, J. Grossiord, L. Moine and F. Agnely, Soft Matter, 2013, 9, 1929 DOI: 10.1039/C2SM27066H

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