Issue 5, 2012
From the journal:

MedChemComm

The synthesis and receptor binding affinities of DDD-016, a novel, potential, atypical antipsychotic†

Achintya Bandyopadhyaya,a   Desikan R. Rajagopalan,a   Nigam P. Rath,b   Amy Herrold,c   Raghavan Rajagopalan,a   T. Celesete Napier,c   Clark E. Tedfordd  and  Parthasarathi Rajagopalan*a  

* Corresponding authors

a Daya Drug Discoveries, Inc., University of Missouri, St. Louis, One University Blvd., St. Louis, Missouri 63121, USA
E-mail: ramajayam30@yahoo.com
Fax: +1 314-516-5342
Tel: +1 636-541-5863

b University of Missouri, St. Louis, One University Blvd., St. Louis, Missouri 63121, USA
E-mail: nprath@umsl.edu
Fax: +1 314-516-5342
Tel: +1 636-541-5863/314-516-5331

c Department of Pharmacology, Rush University Medical Center, 1735 W. Harrison St. Chicago, Illinois 60605, USA
E-mail: celeste_napier@rush.edu
Fax: +1 312-563-3552
Tel: +1 312-563-2416

d Photo Thera, 5925 Priestly Drive, Suite 120, Carlsbad, California 92008, USA
E-mail: ctedford@photothera.com
Fax: +1 760-496-0322
Tel: +1 760-692-4942

Abstract

A new pentacyclic compound, DDD-016 (10d) was designed and synthesized as a potential antipsychotic and screened for binding affinity in a broad panel of over 80 CNS and other receptors, monoamine transporters, and ion channels. The resulting receptor binding profile of DDD-016 is consistent with that of an improved atypical antipsychotic candidate.

Graphical abstract: The synthesis and receptor binding affinities of DDD-016, a novel, potential, atypical antipsychotic

About
Cited by
Related
Download options Please wait...

Supplementary files

Article information

DOI
https://doi.org/10.1039/C2MD00311B
Article type
Concise Article
Submitted
21 Dec 2011
Accepted
06 Mar 2012
First published
07 Mar 2012

Med. Chem. Commun., 2012,3, 580-583

Permissions

Request permissions

The synthesis and receptor binding affinities of DDD-016, a novel, potential, atypical antipsychotic

A. Bandyopadhyaya, D. R. Rajagopalan, N. P. Rath, A. Herrold, R. Rajagopalan, T. C. Napier, C. E. Tedford and P. Rajagopalan, Med. Chem. Commun., 2012, 3, 580 DOI: 10.1039/C2MD00311B

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Spotlight

Advertisements