Issue 48, 2012
From the journal:

Journal of Materials Chemistry

Improved anti-proliferative effect of doxorubicin-containing polymernanoparticles upon surface modification with cationic groups†

Sai Archana Krovi,a   Elden P. Swindell,b   Thomas V. O'Hallorana  and  SonBinh T. Nguyen*a  

* Corresponding authors

a Department of Chemistry, Chemistry of Life Processes Institute, Northwestern University, 2145 Sheridan Road, Evanston, IL, USA
E-mail: stn@northwestern.edu
Fax: +1-847-491-7713
Tel: +1-847-467-3347

b Department of Chemical and Biological Engineering, Northwestern University, 2145 Sheridan Road, Evanston, IL, 60208 USA

Abstract

Polymer nanoparticles (PNPs) possessing a high density of drug payload have been successfully stabilized against aggregation in biological buffers after amine modification, which renders these PNPs positively charged. The resulting charge-stabilized PNPs retain their original narrow particle size distributions and well-defined spherical morphologies. This stabilization allows these PNPs to have an improved anti-proliferative effect on MDA-MB-231-Br human breast cancer cells compared to non-functionalized PNPs. As a non-cytotoxic control, similar surface-modified PNPs containing cholesterol in place of doxorubicin did not inhibit cell proliferation, indicating that the induced cytotoxic response was solely due to the doxorubicin release from the PNPs.

Graphical abstract: Improved anti-proliferative effect of doxorubicin-containing polymer nanoparticles upon surface modification with cationic groups

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Article information

DOI
https://doi.org/10.1039/C2JM35420A
Article type
Paper
Submitted
12 Aug 2012
Accepted
29 Oct 2012
First published
12 Nov 2012

J. Mater. Chem., 2012,22, 25463-25470

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Improved anti-proliferative effect of doxorubicin-containing polymer nanoparticles upon surface modification with cationic groups

S. A. Krovi, E. P. Swindell, T. V. O'Halloran and S. T. Nguyen, J. Mater. Chem., 2012, 22, 25463 DOI: 10.1039/C2JM35420A

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