Issue 38, 2012
From the journal:

Journal of Materials Chemistry

Synthesis of phospholipid monolayer membrane functionalized graphene for drug delivery†

Jiyang Liu,ab   Shaojun Guo,ab   Lei Han,ab   Tianshu Wang,ac   Wei Hong,ab   Yaqing Liu*ab  and  Erkang Wang*ab  

* Corresponding authors

a State Key Laboratory of Electroanalytical Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, China
E-mail: yaqingliu@ciac.jl.cn, ekwang@ciac.jl.cn
Fax: +86-431-85689711

b Graduate School of the Chinese Academy of Sciences, Beijing, China

c College of Physics, Jilin University, Changchun 130012, China

Abstract

In this contribution, lipid monolayer membrane functionalized graphene sheets were prepared using a facile method. Interactions between the graphene and different types of liposomes, including charged and neutral, were also investigated. We found that the anionic liposomes could spontaneously self-organize into lipid monolayer membranes, partially covering the surface of graphene sheets. The resultant lipid monolayer functionalized graphene nanomaterials exhibited high stability in aqueous solution and an excellent performance as carrier for loading the anticancer drug, doxorubicin (DOX), with a high loading capacity of 70%. The loaded drug can be released under pH control. 10% and 14% of the bound DOX was released after 54 h at pH 10.0 and 7.0, respectively. Whereas, about 70% of DOX was released after 54 h at pH 5.0.

Graphical abstract: Synthesis of phospholipid monolayer membrane functionalized graphene for drug delivery

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Supplementary files

Article information

DOI
https://doi.org/10.1039/C2JM34494G
Article type
Paper
Submitted
10 Jul 2012
Accepted
16 Aug 2012
First published
16 Aug 2012

J. Mater. Chem., 2012,22, 20634-20640

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Synthesis of phospholipid monolayer membrane functionalized graphene for drug delivery

J. Liu, S. Guo, L. Han, T. Wang, W. Hong, Y. Liu and E. Wang, J. Mater. Chem., 2012, 22, 20634 DOI: 10.1039/C2JM34494G

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