Issue 35, 2012
From the journal:

Journal of Materials Chemistry

Construction of therapeutic glycopeptide hydrogel as a new substitute for antiproliferative drugs to inhibit postoperative scarring formation

Xiao-Ding Xu,†a   Liang Liang,†bc   Han Cheng,a   Xin-Hua Wang,c   Fa-Gang Jiang,c   Ren-Xi Zhuoa  and  Xian-Zheng Zhang*a  

* Corresponding authors

a Key Laboratory of Biomedical Polymers of Ministry of Education & Department of Chemistry, Wuhan University, Wuhan 430072, P. R. China
E-mail: xz-zhang@whu.edu.cn
Fax: +86-27-68754509
Tel: +86-27-68755993

b Yichang Central People's Hospital, Department of Ophthalmology, China Three Gorges University, Yichang 443003, P. R. China

c Department of Ophthalmology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, P. R. China

Abstract

A biocompatible glycopeptide comprised of an N-fluorenyl-9-methoxycarbonyl phenylalanine-phenylalanine-aspartic acid (FMOC-Phe-Phe-Asp) sequence and a therapeutic glucosamine moiety was designed and synthesized. When dissolving the glycopeptide in PBS solution (pH 7.4), a hydrogel can be formed via the self-assembly of the glycopeptide. Spectroscopic techniques indicate that the self-assembly of the glycopeptide is built on hydrogen bonding interactions between the peptide backbones and π-stacking of FMOC tails. After the administration of this therapeutic glycopeptide hydrogel in filtration surgery of rabbit eyes, due to the glucosamine moieties of the hydrogel inhibiting fibrosis, blebs and filtration fistula formed after the filtration surgery are patent without postoperative scarring formation, resulting in very low intraocular pressure (IOP) of the rabbit eyes within 21 days after surgery. In comparison with traditional antiproliferative drug injections administrated after glaucoma-filtering surgery, the intraoperative administration of this glycopeptide hydrogel can achieve an equivalent therapeutic effect. Importantly, the intraoperative administration of this therapeutic glycopeptide hydrogel has potential advantages including providing convenience and preventing the toxicity of antiproliferative drugs to the ocular tissues, presenting a significant potential alternative for the treatment of glaucoma.

Graphical abstract: Construction of therapeutic glycopeptide hydrogel as a new substitute for antiproliferative drugs to inhibit postoperative scarring formation

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Article information

DOI
https://doi.org/10.1039/C2JM32519E
Article type
Paper
Submitted
22 Apr 2012
Accepted
12 Jul 2012
First published
13 Jul 2012

J. Mater. Chem., 2012,22, 18164-18171

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Construction of therapeutic glycopeptide hydrogel as a new substitute for antiproliferative drugs to inhibit postoperative scarring formation

X. Xu, L. Liang, H. Cheng, X. Wang, F. Jiang, R. Zhuo and X. Zhang, J. Mater. Chem., 2012, 22, 18164 DOI: 10.1039/C2JM32519E

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