Issue 90, 2012
From the journal:

Chemical Communications

Heteroaromatic imidazo[1,2-a]pyridines synthesis from C–H/N–H oxidative cross-coupling/cyclization†

Chuan He,a   Jing Hao,a   Huan Xu,a   Yiping Mo,a   Huiying Liu,a   Juanjuan Hana  and  Aiwen Lei*ab  

* Corresponding authors

a College of Chemistry and Molecular Sciences, Wuhan University, P. R. China
E-mail: aiwenlei@whu.edu.cn
Fax: +86-27-68754067

b State Key Laboratory for Oxo Synthesis and Selective Oxidation, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences, Lanzhou, P. R. China

Abstract

A novel silver-mediated highly selective C–H/N–H oxidative cross-coupling/cyclization between 2-aminopyridines and terminal alkynes has been demonstrated. This approach provided a simple way to construct heteroaromatic imidazo[1,2-a]pyridines. By using this protocol, the marketed drug zolimidine (antiulcer) could be synthesized easily.

Graphical abstract: Heteroaromatic imidazo[1,2-a]pyridines synthesis from C–H/N–H oxidative cross-coupling/cyclization

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Article information

DOI
https://doi.org/10.1039/C2CC35927H
Article type
Communication
Submitted
16 Aug 2012
Accepted
12 Sep 2012
First published
13 Sep 2012

Chem. Commun., 2012,48, 11073-11075

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Heteroaromatic imidazo[1,2-a]pyridines synthesis from C–H/N–H oxidative cross-coupling/cyclization

C. He, J. Hao, H. Xu, Y. Mo, H. Liu, J. Han and A. Lei, Chem. Commun., 2012, 48, 11073 DOI: 10.1039/C2CC35927H

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