Issue 43, 2012
From the journal:

Chemical Communications

Biomimetic detection of aminoglycosidic antibiotics using polydiacetylene–phospholipids supramolecules†

Do Hyun Kang,‡ab   Ho-Sup Jung,‡a   Namyoung Ahn,a   Jiseok Lee,c   Sungbaek Seo,c   Kahp-Yang Suh,abd   Jinsang Kim*ce  and  Keesung Kim*ad  

* Corresponding authors

a School of Mechanical and Aerospace Engineering, Seoul National University, Seoul 151-742, Korea

b Division of WCU Multiscale Mechanical Design, School of Mechanical and Aerospace Engineering, Seoul National University, Seoul 151-742, Korea

c Macromolecular Science and Engineering, University of Michigan, 2300 Hayward St., Ann Arbor, USA

d Institute of Advanced Machinery and Design, Seoul National University, Seoul 151-742, Korea
E-mail: keesung@snu.ac.kr
Fax: +82-2-889-6205
Tel: +82-2-883-7301

e Materials Science and Engineering, Chemical Engineering, Biomedical Engineering, University of Michigan, 2300 Hayward St., Ann Arbor, USA
E-mail: Jinsang@umich.edu

Abstract

We rationally designed highly sensitive and selective polydiacetylene (PDA)–phospholipids liposomes for the facile detection of aminoglycosidic antibiotics. The detecting mechanism mimics the cellular membrane interactions between neomycin and phosphatidylinositol-4,5-bisphosphate (PIP2) phospholipids. The developed PDA–PIP2 sensory system showed a detection limit of 61 ppb for neomycin and was very specific to aminoglycosidic antibodies only.

Graphical abstract: Biomimetic detection of aminoglycosidic antibiotics using polydiacetylene–phospholipids supramolecules

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Article information

DOI
https://doi.org/10.1039/C2CC31466E
Article type
Communication
Submitted
27 Feb 2012
Accepted
28 Mar 2012
First published
17 Apr 2012

Chem. Commun., 2012,48, 5313-5315

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Biomimetic detection of aminoglycosidic antibiotics using polydiacetylene–phospholipids supramolecules

D. H. Kang, H. Jung, N. Ahn, J. Lee, S. Seo, K. Suh, J. Kim and K. Kim, Chem. Commun., 2012, 48, 5313 DOI: 10.1039/C2CC31466E

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