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Light-triggered conversion of non-ionic into ionic surfactants: towards chameleon detergents for 2-D gel electrophoresis

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Abstract

Caged non-ionic detergents, comprised of polar oligo(ethylene glycol) and non-polar alkyl chains joined by a photocleavable ortho-nitrobenzyl sulfonate linker have been synthesized and characterized. The light-triggered transformation of such chameleon surfactant from a charge-neutral into a charged form offers great potential to improve 2-D gel electrophoretic separation of complex protein mixtures.

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Authors and Affiliations

  1. Institut für Chemie - Biochemie, Freie Universität Berlin, Thielallee 63, 14195, Berlin, Germany

    Oliver Bogen, Hans Daroszi, Mathias Dreger & Ferdinand Hucho

  2. Institut für Chemie–Organische Chemie, Freie Universität Berlin, Takustr., 3, 14195, Berlin, Germany

    Petar Milosevic & Stefan Hecht

  3. Department of Chemistry, Humboldt-Universität zu Berlin, Germany

    Stefan Hecht

Authors
  1. Oliver Bogen
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  2. Petar Milosevic
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  3. Hans Daroszi
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  4. Mathias Dreger
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  5. Stefan Hecht
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  6. Ferdinand Hucho
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Corresponding authors

Correspondence to Stefan Hecht or Ferdinand Hucho.

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Bogen, O., Milosevic, P., Daroszi, H. et al. Light-triggered conversion of non-ionic into ionic surfactants: towards chameleon detergents for 2-D gel electrophoresis. Photochem Photobiol Sci 11, 497–499 (2012). https://doi.org/10.1039/c1pp05316g

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  • DOI: https://doi.org/10.1039/c1pp05316g

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