Issue 1, 2012
From the journal:

Molecular BioSystems

An omics perspective of protein disorder†

Jeremy Bellay,‡a   Magali Michaut,bc   TaeHyung Kim,bc   Sangjo Han,bc   Recep Colak,be   Chad L. Myersa  and  Philip M. Kim*bcde  

* Corresponding authors

a Department of Computer Science and Engineering, University of Minnesota, Minneapolis, MN, USA

b Terrence Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, Canada
E-mail: pi@kimlab.org
Fax: +1 416 978 8287
Tel: +1 416 946 3419

c Banting and Best Department of Medical Research, University of Toronto, Toronto, Canada

d Department of Molecular Genetics, University of Toronto, Toronto, Canada

e Department of Computer Science, University of Toronto, Toronto, Canada

Abstract

Disordered regions within proteins have increasingly been associated with various cellular functions. Identifying the specific roles played by disorder in these functions has proved difficult. However, the development of reliable prediction algorithms has expanded the study of disorder from a few anecdotal examples to a proteome-wide scale. Moreover, the recent omics revolution has provided the sequences of numerous organisms as well as thousands of genome-wide data sets including several types of interactomes. Here, we review the literature regarding genome-wide studies of disorder and examine how these studies give rise to new characterizations and categories of this elusive phenomenon.

Graphical abstract: An omics perspective of protein disorder

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Article information

DOI
https://doi.org/10.1039/C1MB05235G
Article type
Review Article
Submitted
14 Jun 2011
Accepted
29 Oct 2011
First published
18 Nov 2011

Mol. BioSyst., 2012,8, 185-193

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An omics perspective of protein disorder

J. Bellay, M. Michaut, T. Kim, S. Han, R. Colak, C. L. Myers and P. M. Kim, Mol. BioSyst., 2012, 8, 185 DOI: 10.1039/C1MB05235G

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