Issue 26, 2011
From the journal:

Chemical Communications

A small molecule antagonist of ghrelin O-acyltransferase (GOAT)†

Amanda L. Garnera  and  Kim D. Janda*a  

* Corresponding authors

a Departments of Chemistry and Immunology and Microbial Science, The Skaggs Institute for Chemical Biology and The Worm Institute for Research and Medicine, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, USA
E-mail: kdjanda@scripps.edu
Fax: (+1) 858-784-2595
Tel: (+1) 858-784-2515

Abstract

Using our recently disclosed fluorescence-based assay to monitor acyltransferase activity, the first non-peptidic, small molecule antagonists of ghrelin O-acyltransferase (GOAT), a potential anti-obesity and anti-diabetes target, have been discovered. Each exhibits micromolar inhibition of the enzyme, and may be useful probes for future study of the ghrelin-GOAT system.

Graphical abstract: A small molecule antagonist of ghrelin O-acyltransferase (GOAT)

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Article information

DOI
https://doi.org/10.1039/C1CC11817J
Article type
Communication
Submitted
30 Mar 2011
Accepted
26 Apr 2011
First published
19 May 2011

Chem. Commun., 2011,47, 7512-7514

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A small molecule antagonist of ghrelin O-acyltransferase (GOAT)

A. L. Garner and K. D. Janda, Chem. Commun., 2011, 47, 7512 DOI: 10.1039/C1CC11817J

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