Issue 20, 2011

Caged molecular beacons: controlling nucleic acid hybridization with light

Abstract

We have constructed a novel class of light-activatable caged molecular beacons (cMBs) that are caged by locking two stems with a photo-labile biomolecular interaction or covalent bond. With the cMBs, the nucleic acid hybridization process can be easily controlled with light, which offers the possibility for a high spatiotemporal resolution study of intracellular mRNAs.

Graphical abstract: Caged molecular beacons: controlling nucleic acid hybridization with light

Supplementary files

Article information

Article type
Communication
Submitted
24 Jan 2011
Accepted
04 Apr 2011
First published
18 Apr 2011

Chem. Commun., 2011,47, 5708-5710

Caged molecular beacons: controlling nucleic acid hybridization with light

C. Wang, Z. Zhu, Y. Song, H. Lin, C. J. Yang and W. Tan, Chem. Commun., 2011, 47, 5708 DOI: 10.1039/C1CC10481K

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