Issue 1, 2011

Water-solubilisation and bio-conjugation of a red-emitting BODIPY marker

Abstract

The synthesis and preliminary bio-conjugation studies of a novel water-soluble red-emitting di-styryl BODIPY dye are disclosed. Aggregation behaviour of this compound under physiological conditions was suppressed by specific introduction of a di-sulfonated peptide-based linker at the mesophenyl substituent, sultonated styryl arms and short polyethyleneglycol chains at the boron center. Thus, a good quantum yield of 22% in PBS for this red-emitting BODIPY was obtained. Introduction of an activated ester function enabled successful bio-conjugation to monoclonal antibodies and proteins.

Graphical abstract: Water-solubilisation and bio-conjugation of a red-emitting BODIPY marker

Supplementary files

Article information

Article type
Communication
Submitted
07 Sep 2010
Accepted
29 Oct 2010
First published
18 Nov 2010

Org. Biomol. Chem., 2011,9, 66-69

Water-solubilisation and bio-conjugation of a red-emitting BODIPY marker

S. L. Niu, C. Massif, G. Ulrich, R. Ziessel, P. Renard and A. Romieu, Org. Biomol. Chem., 2011, 9, 66 DOI: 10.1039/C0OB00693A

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