Issue 5, 2010
From the journal:

MedChemComm

The kinetics of bulk hydration of the disaccharides α-lactose and trehalose by in situneutron powder diffraction†

Valeska P. Ting,a   Marc Schmidtmann,b   Paul F. Henry,c   Sandie E. Dann,d   Jenna L. Crisp,d   Chick C. Wilsonb  and  Mark T. Weller*a  

* Corresponding authors

a School of Chemistry, University of Southampton, U.K.
E-mail: mtw@soton.ac.uk
Fax: +44 23 8059 33781
Tel: +44 23 8059 3592

b WestCHEM, Department of Chemistry, University of Glasgow, U.K.
E-mail: c.c.wilson@chem.gla.ac.uk
Tel: +44 141 330 8522

c MI-1, Helmholtz Zentrum Berlin für Materialien und Energie, Berlin, Germany
E-mail: paul.henry@helmholtz-berlin.de
Tel: +49 30 8062 2686

d Department of Chemistry, Loughborough University, U.K.
E-mail: s.e.dann@lboro.ac.uk

Abstract

The hydrations of the excipients stable α-lactose (Lαs), with two particle sizes, and trehalose have been studied by neutron powder diffraction; analysis of the Avrami plots, derived from the bulk polycrystalline phase compositions, allows elucidation of the kinetics and mechanisms involved in these hydration processes.

Graphical abstract: The kinetics of bulk hydration of the disaccharides α-lactose and trehalose by in situ neutron powder diffraction

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Article information

DOI
https://doi.org/10.1039/C0MD00093K
Article type
Concise Article
Submitted
30 Jun 2010
Accepted
21 Sep 2010
First published
11 Oct 2010

Med. Chem. Commun., 2010,1, 345-348

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The kinetics of bulk hydration of the disaccharides α-lactose and trehalose by in situ neutron powder diffraction

V. P. Ting, M. Schmidtmann, P. F. Henry, S. E. Dann, J. L. Crisp, C. C. Wilson and M. T. Weller, Med. Chem. Commun., 2010, 1, 345 DOI: 10.1039/C0MD00093K

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