Issue 13, 2011
From the journal:

Chemical Communications

Enantioselective aza-Michael reaction of hydrazide to chalcones through the nonactivated amine moiety conjugated addition†

Jun Jiang,a   Yunfei Cai,a   Weiliang Chen,a   Lili Lin,a   Xiaohua Liua  and  Xiaoming Feng*a  

* Corresponding authors

a Key Laboratory of Green Chemistry & Technology, Ministry of Education, College of Chemistry, Sichuan University, Chengdu 610064, China
E-mail: xmfeng@scu.edu.cn
Fax: +862885418249
Tel: +862885418249

Abstract

The catalytic asymmetric aza-Michael reaction of benzoyl hydrazine toward chalcones through the nonactivated amine moiety conjugated addition was facilitated by the developed N,N′-dioxide-Sc(OTf)3 complex under mild conditions, affording the pharmacologically and synthetically useful products in moderate to high yields with up to 97% ee.

Graphical abstract: Enantioselective aza-Michael reaction of hydrazide to chalcones through the nonactivated amine moiety conjugated addition

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Article information

DOI
https://doi.org/10.1039/C0CC05804A
Article type
Communication
Submitted
27 Dec 2010
Accepted
26 Jan 2011
First published
23 Feb 2011

Chem. Commun., 2011,47, 4016-4018

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Enantioselective aza-Michael reaction of hydrazide to chalcones through the nonactivated amine moiety conjugated addition

J. Jiang, Y. Cai, W. Chen, L. Lin, X. Liu and X. Feng, Chem. Commun., 2011, 47, 4016 DOI: 10.1039/C0CC05804A

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