Issue 7, 2011
From the journal:

Chemical Communications

Osmium(vi) complexes as a new class of potential anti-cancer agents†

Wen-Xiu Ni,a   Wai-Lun Man,a   Myra Ting-Wai Cheung,a   Raymond Wai-Yin Sun,b   Yuan-Lan Shu,c   Yun-Wah Lam,*a   Chi-Ming Che*b  and  Tai-Chu Lau*a  

* Corresponding authors

a Department of Biology and Chemistry, City University of Hong Kong, Tat Chee Avenue, Kowloon Tong, Hong Kong, China
E-mail: bhtclau@cityu.edu.hk

b Department of Chemistry and Open Laboratory of Chemical Biology of the Institute of Molecular Technology for Drug Discovery and Synthesis, The University of Hong Kong, Pokfulam Road, Hong Kong, China
E-mail: cmche@hku.hk

c State Key Laboratory Incubation Base of Chinese Medicine and Molecular Pharmacology, Shenzhen, China

Abstract

A nitridoosmium(VI) complex [OsVI(N)(sap)(OH2)Cl] (H2sap = N-salicylidene-2-aminophenol) displays prominent in vitro and in vivo anti-cancer properties, induces S- and G2/M-phase arrest and forms a stable adduct with dianionic 5′-guanosine monophosphate.

Graphical abstract: Osmium(vi) complexes as a new class of potential anti-cancer agents

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Article information

DOI
https://doi.org/10.1039/C0CC04515B
Article type
Communication
Submitted
20 Oct 2010
Accepted
06 Dec 2010
First published
04 Jan 2011

Chem. Commun., 2011,47, 2140-2142

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Osmium(VI) complexes as a new class of potential anti-cancer agents

W. Ni, W. Man, M. T. Cheung, R. W. Sun, Y. Shu, Y. Lam, C. Che and T. Lau, Chem. Commun., 2011, 47, 2140 DOI: 10.1039/C0CC04515B

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