Issue 31, 2010

Chemoenzymatic synthesis of glycosylphosphatidylinositol-anchored glycopeptides

Abstract

MUC1 glycopeptide was efficiently coupled to glycosylphosphatidylinositol (GPI) derivatives by sortase A (SrtA), verifying that SrtA can accept sterically hindered glycopeptide as substrate for ligation with GPIs. This work has established a practical method for the chemoenzymatic synthesis of GPI-linked glycopeptides.

Graphical abstract: Chemoenzymatic synthesis of glycosylphosphatidylinositol-anchored glycopeptides

Supplementary files

Article information

Article type
Communication
Submitted
08 Apr 2010
Accepted
26 May 2010
First published
24 Jun 2010

Chem. Commun., 2010,46, 5773-5774

Chemoenzymatic synthesis of glycosylphosphatidylinositol-anchored glycopeptides

Z. Wu, X. Guo and Z. Guo, Chem. Commun., 2010, 46, 5773 DOI: 10.1039/C0CC00828A

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