Issue 31, 2010
From the journal:

Chemical Communications

Unusual radical addition on a heteroaromatic nitrogen. A convenient access to new pyrimidine derivatives†‡

Yann Laot,a   Laurent Petita  and  Samir Z. Zard*a  

* Corresponding authors

a Laboratoire de Synthèse Organique, CNRS UMR 7652, Ecole Polytechnique, 91128 Palaiseau, France
E-mail: zard@poly.polytechnique.fr
Fax: +33 16933 5972
Tel: +33 16933 5971

Abstract

A radical generated on the side-chain of a 2- or 4-N-alkylamino-4,6- or 2,6-dichloropyrimidine can cyclise on the nitrogen or on the carbon of the pyrimidine ring depending on its position and on whether an acetyl or a Boc group is present on the extra-nuclear nitrogen.

Graphical abstract: Unusual radical addition on a heteroaromatic nitrogen. A convenient access to new pyrimidine derivatives

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Article information

DOI
https://doi.org/10.1039/C0CC00533A
Article type
Communication
Submitted
22 Mar 2010
Accepted
09 Jun 2010
First published
24 Jun 2010

Chem. Commun., 2010,46, 5784-5786

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Unusual radical addition on a heteroaromatic nitrogen. A convenient access to new pyrimidine derivatives

Y. Laot, L. Petit and S. Z. Zard, Chem. Commun., 2010, 46, 5784 DOI: 10.1039/C0CC00533A

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