Issue 4, 2011
From the journal:

Analyst

Evaluation of aromatic-derivatized cyclofructans 6 and 7 as HPLC chiral selectors

Ping Sun,a   Chunlei Wang,a   Nilusha Lasanthi Thilakarathna Padivitage,a   Yasith S. Nanayakkara,a   Sirantha Perera,a   Haixiao Qiu,a   Ying Zhanga  and  Daniel W. Armstrong*a  

* Corresponding authors

a Department of Chemistry and Biochemistry, The University of Texas at Arlington, Arlington, TX, USA
E-mail: sec4dwa@uta.edu
Fax: +1-817-272-0619
Tel: +1-817-272-0632

Abstract

The two best aromatic-functionalized cyclofructan chiral stationary phases, R-naphthylethyl-carbamate cyclofructan 6 (RN-CF6) and dimethylphenyl-carbamate cyclofructan 7 (DMP-CF7), were synthesized and evaluated by injecting various classes of chiral analytes. They provided enantioselectivity toward a broad range of compounds, including chiral acids, amines, metal complexes, and neutral compounds. It is interesting that they exhibited complementary selectivities and the combination of two columns provided enantiomeric separations for 43% of the test analytes. These extensive chromatographic results provided useful information about method development of specific analytes, and also gave some insight as to the enantioseparation mechanism.

Graphical abstract: Evaluation of aromatic-derivatized cyclofructans 6 and 7 as HPLC chiral selectors

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Article information

DOI
https://doi.org/10.1039/C0AN00653J
Article type
Paper
Submitted
24 Aug 2010
Accepted
31 Oct 2010
First published
07 Dec 2010

Analyst, 2011,136, 787-800

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Evaluation of aromatic-derivatized cyclofructans 6 and 7 as HPLC chiral selectors

P. Sun, C. Wang, N. L. T. Padivitage, Y. S. Nanayakkara, S. Perera, H. Qiu, Y. Zhang and D. W. Armstrong, Analyst, 2011, 136, 787 DOI: 10.1039/C0AN00653J

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