Issue 12, 2010
From the journal:

Organic & Biomolecular Chemistry

Small molecule-mediated inhibition of translation by targeting a native RNAG-quadruplex†

Anthony Bugaut,a   Raphaël Rodriguez,a   Sunita Kumari,a   Shang-Te Danny Hsua  and  Shankar Balasubramanian*ab  

* Corresponding authors

a Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, UK
E-mail: sb10031@cam.ac.uk
Fax: +44 1223 336913
Tel: +44 1223 336347

b School of Clinical Medicine, University of Cambridge, Cambridge, UK

Abstract

Herein, we show that a naturally occurring RNA G-quadruplex element within the 5′ UTR of the human NRAS proto-oncogene is a target for a small molecule that inhibits translation in vitro. The present study provides a first demonstration that natural 5′ UTR mRNA G-quadruplexes have potential as molecular targets for small molecules that modulate translation.

Graphical abstract: Small molecule-mediated inhibition of translation by targeting a native RNA G-quadruplex

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Article information

DOI
https://doi.org/10.1039/C002418J
Article type
Paper
Submitted
04 Feb 2010
Accepted
06 Apr 2010
First published
30 Apr 2010

Org. Biomol. Chem., 2010,8, 2771-2776

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Small molecule-mediated inhibition of translation by targeting a native RNA G-quadruplex

A. Bugaut, R. Rodriguez, S. Kumari, S. D. Hsu and S. Balasubramanian, Org. Biomol. Chem., 2010, 8, 2771 DOI: 10.1039/C002418J

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