Gold-catalyzed efficient synthesis of azepan-4-ones via a two-step [5 + 2] annulation

Li Cui; Longwu Ye; Liming Zhang

doi:10.1039/C001314E

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Gold-catalyzed efficient synthesis of azepan-4-ones via a two-step [5 + 2] annulation†

Li Cui,^a Longwu Ye^a and Liming Zhang*^a

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* Corresponding authors

^a Department of Chemistry and Biochemistry, University of California, Santa Barbara
E-mail: zhang@chem.ucsb.edu
Fax: (+01) (805) 893-4120

Abstract

A surprisingly efficient synthesis of azepan-4-ones via a two-step [5 + 2] annulation is developed. This reaction involves a key gold catalysis and shows generally high regioselectivities and good to excellent diastereoselectivities.

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Article information

DOI: https://doi.org/10.1039/C001314E
Article type: Communication
Submitted: 20 Jan 2010
Accepted: 18 Feb 2010
First published: 30 Mar 2010

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Chem. Commun., 2010,46, 3351-3353

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Gold-catalyzed efficient synthesis of azepan-4-ones via a two-step [5 + 2] annulation

L. Cui, L. Ye and L. Zhang, Chem. Commun., 2010, 46, 3351 DOI: 10.1039/C001314E

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