Issue 19, 2010
From the journal:

Chemical Communications

Copper-promoted N-cyclopropylation of anilines and amines by cyclopropylboronic acid†

Sébastien Bénard,a   Luc Neuville*a  and  Jieping Zhu*a  

* Corresponding authors

a Centre de Recherche de Gif, Institut de Chimie des Substances Naturelles, CNRS, 91198 Gif-sur-Yvette, France
E-mail: zhu@icsn.cnrs-gif.fr, neuville@icsn.cnrs-gif.fr
Fax: 33(0)1-69-07-72-47
Tel: 33 (0)1-69-82-45-77

Abstract

Reaction of anilines, primary and secondary aliphatic amines with cyclopropylboronic acid in dichloroethane in the presence of Cu(OAc)2 (1 equiv.), 2,2′-bipyridine (1 equiv.) and sodium carbonate or sodium bicarbonate (2 equiv.) under air atmosphere afforded the corresponding N-cyclopropyl derivatives in good to excellent yields.

Graphical abstract: Copper-promoted N-cyclopropylation of anilines and amines by cyclopropylboronic acid

About
Cited by
Related
Download options Please wait...

Supplementary files

Article information

DOI
https://doi.org/10.1039/B925499D
Article type
Communication
Submitted
03 Dec 2009
Accepted
04 Mar 2010
First published
01 Apr 2010

Chem. Commun., 2010,46, 3393-3395

Permissions

Request permissions

Copper-promoted N-cyclopropylation of anilines and amines by cyclopropylboronic acid

S. Bénard, L. Neuville and J. Zhu, Chem. Commun., 2010, 46, 3393 DOI: 10.1039/B925499D

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements