Biosensor system-on-a-chip including CMOS-based signal processing circuits and 64 carbon nanotube-based sensors for the detection of a neurotransmitter

Byung Yang Lee; Sung Min Seo; Dong Joon Lee; Minbaek Lee; Joohyung Lee; Jun-Ho Cheon; Eunju Cho; Hyunjoong Lee; In-Young Chung; Young June Park; Suhwan Kim; Seunghun Hong

doi:10.1039/B916975J

Biosensor system-on-a-chip including CMOS-based signal processing circuits and 64 carbon nanotube-based sensors for the detection of a neurotransmitter†

Byung Yang Lee,‡^ab Sung Min Seo,‡^ac Dong Joon Lee,^ab Minbaek Lee,^ab Joohyung Lee,^ab Jun-Ho Cheon,^ac Eunju Cho,^ab Hyunjoong Lee,^ac In-Young Chung,^d Young June Park,*^ac Suhwan Kim*^ac and Seunghun Hong*^ab

Author affiliations

* Corresponding authors

^a Nano-Systems Institute, Seoul National University, Seoul, Korea

^b Physics and Astronomy, Seoul National University, Seoul, Korea
E-mail: seunghun@snu.ac.kr

^c Electrical Engineering, Seoul National University, Seoul, Korea
E-mail: ypark@snu.ac.kr, suhwan@snu.ac.kr

^d Electronics and Communications Engineering, Kwangwoon University, Seoul, Korea

Abstract

We developed a carbon nanotube (CNT)-based biosensor system-on-a-chip (SoC) for the detection of a neurotransmitter. Here, 64 CNT-based sensors were integrated with silicon-based signal processing circuits in a single chip, which was made possible by combining several technological breakthroughs such as efficient signal processing, uniform CNT networks, and biocompatible functionalization of CNT-based sensors. The chip was utilized to detect glutamate, a neurotransmitter, where ammonia, a byproduct of the enzymatic reaction of glutamate and glutamate oxidase on CNT-based sensors, modulated the conductance signals to the CNT-based sensors. This is a major technological advancement in the integration of CNT-based sensors with microelectronics, and this chip can be readily integrated with larger scale lab-on-a-chip (LoC) systems for various applications such as LoC systems for neural networks.

Lab on a Chip

Biosensor system-on-a-chip including CMOS-based signal processing circuits and 64 carbon nanotube-based sensors for the detection of a neurotransmitter†

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