Issue 1, 2010
From the journal:

Chemical Society Reviews

Responsive magnetic resonance imaging contrast agents as chemical sensors for metals in biology and medicine

Emily L. Quea  and  Christopher J. Chang*ab  

* Corresponding authors

a Department of Chemistry, University of California, Berkeley, USA

b The Howard Hughes Medical Institute, University of California, Berkeley, USA
E-mail: chrischang@berkeley.edu

Abstract

This tutorial review highlights progress in the development of responsive magnetic resonance imaging (MRI) contrast agents for detecting and sensing biologically relevant metal ions. Molecular imaging with bioactivatable MRI indicators offers a potentially powerful methodology for studying the physiology and pathology of metals by capturing dynamic three-dimensional images of living systems for research and clinical applications. This emerging area at the interface of inorganic chemistry and the life sciences offers a broad palette of opportunities for researchers with interests ranging from coordination chemistry and spectroscopy to supramolecular chemistry and molecular recognition to metals in biology and medicine.

Graphical abstract: Responsive magnetic resonance imaging contrast agents as chemical sensors for metals in biology and medicine

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Article information

DOI
https://doi.org/10.1039/B914348N
Article type
Tutorial Review
Submitted
22 Jul 2009
First published
07 Oct 2009

Chem. Soc. Rev., 2010,39, 51-60

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Responsive magnetic resonance imaging contrast agents as chemical sensors for metals in biology and medicine

E. L. Que and C. J. Chang, Chem. Soc. Rev., 2010, 39, 51 DOI: 10.1039/B914348N

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