Issue 48, 2009

Dual anti-angiogenic and cytotoxic properties of ruthenium(iii) complexes containing pyrazolato and/or pyrazole ligands

Abstract

An oxo-bridged diruthenium(III) complex containing pyrazolato and pyrazole ligands is stable against ascorbic-acid reduction, induces apoptosis (60%, 48 h) against HeLa cells at 10 μM level and exhibits promising anti-angiogenic activity at its sub-cytotoxic concentrations. Other mononuclear ruthenium(III) complexes containing pyrazole ligands [Ru(pz)4X2]+ exhibit dual anti-angiogenic and cytotoxic properties.

Graphical abstract: Dual anti-angiogenic and cytotoxic properties of ruthenium(iii) complexes containing pyrazolato and/or pyrazole ligands

Supplementary files

Article information

Article type
Communication
Submitted
22 Jun 2009
Accepted
02 Sep 2009
First published
14 Sep 2009

Dalton Trans., 2009, 10712-10716

Dual anti-angiogenic and cytotoxic properties of ruthenium(III) complexes containing pyrazolato and/or pyrazole ligands

R. W. Sun, M. F. Ng, E. L. Wong, J. Zhang, S. S. Chui, L. Shek, T. Lau and C. Che, Dalton Trans., 2009, 10712 DOI: 10.1039/B912236B

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