Issue 21, 2009
From the journal:

Chemical Communications

Using aptamers evolved from cell-SELEX to engineer a molecular delivery platform†

Prabodhika Mallikaratchy,a   Haipeng Liu,a   Yu Fen Huang,a   Hui Wang,a   Dalia Lopez-Colona  and  Weihong Tan*a  

* Corresponding authors

a Department of Chemistry and Physiology and Functional Genomics, Center for Research at the Bio/Nano interface, Shands Cancer Center, UF Genetics Institute, McKnight Brain Institute, University of Florida, Gainesville, USA
E-mail: tan@chem.ufl.edu
Fax: +1 3 52 846 2410

Abstract

We report a chemically modified construct of the Sgc8 aptamer, selected against CEM cells, conjugated to an activator platform for stimulated release of molecules at the tumor surface using DNA template assisted functional group transfer reactions (DTGTR).

Graphical abstract: Using aptamers evolved from cell-SELEX to engineer a molecular delivery platform

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Article information

DOI
https://doi.org/10.1039/B823258J
Article type
Communication
Submitted
24 Dec 2008
Accepted
19 Mar 2009
First published
09 Apr 2009

Chem. Commun., 2009, 3056-3058

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Using aptamers evolved from cell-SELEX to engineer a molecular delivery platform

P. Mallikaratchy, H. Liu, Y. F. Huang, H. Wang, D. Lopez-Colon and W. Tan, Chem. Commun., 2009, 3056 DOI: 10.1039/B823258J

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