Issue 4, 2009
From the journal:

Green Chemistry

Highly enantioselective l-thiaproline catalyzed α-aminoxylation of aldehydes in aqueous media†

Pei Juan Chua,a   Bin Tana  and  Guofu Zhong*a  

* Corresponding authors

a Division of Chemistry & Biological Chemistry, School of Physical & Mathematical Sciences, Nanyang Technological University, 21 Nanyang Link, Singapore, Singapore
E-mail: guofu@ntu.edu.sg
Fax: +65 6791 1961
Tel: +65 6316 8761

Abstract

Highly enantioselective L-thiaproline catalyzed α-aminoxylation of aldehydes in the presence of water and tetrabutylammonium bromide followed by in situreduction to afford the respective α-aminoxy alcohols has been developed in good to high yields (74–88%) and excellent enantioselectivities (93–>99%).

Graphical abstract: Highly enantioselective l-thiaproline catalyzed α-aminoxylation of aldehydes in aqueous media

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Article information

DOI
https://doi.org/10.1039/B817950F
Article type
Paper
Submitted
15 Oct 2008
Accepted
28 Jan 2009
First published
13 Feb 2009

Green Chem., 2009,11, 543-547

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Highly enantioselective L-thiaproline catalyzed α-aminoxylation of aldehydes in aqueous media

P. J. Chua, B. Tan and G. Zhong, Green Chem., 2009, 11, 543 DOI: 10.1039/B817950F

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