Issue 44, 2008
From the journal:

Chemical Communications

Trifluoromethyldiazirine: an effective photo-induced cross-linking probe for exploring amyloid formation†

David P. Smith,a   Jon Anderson,b   Jeffrey Plante,ab   Alison E. Ashcroft,a   Sheena E. Radford,a   Andrew J. Wilson*ab  and  Martin J. Parker*a  

* Corresponding authors

a Astbury Centre for Structural Molecular Biology, University of Leeds, Woodhouse Lane, Leeds, UK
E-mail: M.J.Parker@leeds.ac.uk
Tel: +44 (0)113 343 1408

b School of Chemistry, University of Leeds, Woodhouse Lane, Leeds, UK
E-mail: A.J.Wilson@leeds.ac.uk
Fax: +44 (0)113 3431409
Tel: +44 (0)113 3436565

Abstract

The separative and analytical power of ion mobility spectrometry-mass spectrometry combined with photo-induced cross-linking of site-specifically incorporated trifluoromethyldiazirine provides a powerful approach towards structural characterisation of amyloid fibrils.

Graphical abstract: Trifluoromethyldiazirine: an effective photo-induced cross-linking probe for exploring amyloid formation

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Article information

DOI
https://doi.org/10.1039/B813504E
Article type
Communication
Submitted
04 Aug 2008
Accepted
05 Sep 2008
First published
30 Sep 2008

Chem. Commun., 2008, 5728-5730

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Trifluoromethyldiazirine: an effective photo-induced cross-linking probe for exploring amyloid formation

D. P. Smith, J. Anderson, J. Plante, A. E. Ashcroft, S. E. Radford, A. J. Wilson and M. J. Parker, Chem. Commun., 2008, 5728 DOI: 10.1039/B813504E

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