Issue 1, 2009

Cleavage of RNA oligonucleotides by aminoglycosides

Abstract

A number of aminoglycoside antibiotics, and in particular neomycin B, are demonstrated to promote strand cleavage of RNA oligonucleotides (minimised HIV-1 TAR element and prokaryotic ribosomal A-site), by binding and causing sufficient distortion to the RNA backbone to render it more susceptible to intramolecular transesterification.

Graphical abstract: Cleavage of RNA oligonucleotides by aminoglycosides

Supplementary files

Article information

Article type
Communication
Submitted
31 Jul 2008
Accepted
22 Oct 2008
First published
30 Oct 2008

Org. Biomol. Chem., 2009,7, 30-33

Cleavage of RNA oligonucleotides by aminoglycosides

M. J. Belousoff, B. Graham, L. Spiccia and Y. Tor, Org. Biomol. Chem., 2009, 7, 30 DOI: 10.1039/B813252F

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