Issue 10, 2008
From the journal:

Lab on a Chip

Long-term storable and shippable lipid bilayer membrane platform†

Tae-Joon Jeon,a   Jason L. Poulosa  and  Jacob J. Schmidt*ab  

* Corresponding authors

a University of California, Los Angeles, Department of Bioengineering, Los Angeles, CA, USA
E-mail: schmidt@seas.ucla.edu
Fax: +1-310-794-5956
Tel: +1-310-267-4985

b University of California, Los Angeles, California Nanosystems Institute (CNSI), Los Angeles, CA, USA

Abstract

The fragility and short lifetimes characteristic of conventionally formed lipid bilayer membranes has necessitated their preparation to be at the time and point of use. By using high freezing-point lipid–solvent mixtures, the process of lipid bilayer self-assembly may be reversibly arrested. In solid form, the bilayer precursor can be stored indefinitely and is sufficiently robust to withstand commercial shipping. Upon thawing, bilayer self-assembly resumes, resulting in a biologically functional membrane. Combination of this membrane precursor with an inexpensive chip results in a compact, practical, and disposable platform for ion channel measurements.

Graphical abstract: Long-term storable and shippable lipid bilayer membrane platform

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Article information

DOI
https://doi.org/10.1039/B807932C
Article type
Technical Note
Submitted
09 May 2008
Accepted
16 Jul 2008
First published
22 Aug 2008

Lab Chip, 2008,8, 1742-1744

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Long-term storable and shippable lipid bilayer membrane platform

T. Jeon, J. L. Poulos and J. J. Schmidt, Lab Chip, 2008, 8, 1742 DOI: 10.1039/B807932C

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