Issue 24, 2008
From the journal:

Chemical Communications

Orthogonal ligation: a three piece assembly of a PNA–peptide–PNA conjugate†

Fabienne Burlina,*a   David D. Dixson,b   Robert P. Doyle,b   Gérard Chassaing,a   Christopher N. Boddy,b   Philip Dawsonc  and  John Offer*d  

* Corresponding authors

a UPMC Univ Paris 06, CNRS UMR 7613, 4 place Jussieu, F-75005 Paris, France
E-mail: fabienne.burlina@upmc.fr

b Department of Chemistry, Syracuse University, Syracuse, USA

c The Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, USA

d Department of Biochemistry, University of Oxford, South Parks Road, Oxford, UK
E-mail: john.offer@bioch.ox.ac.uk

Abstract

A PNA–peptide–PNA conjugate was assembled from three fragments using a combination of native chemical ligation and an orthogonal, auxiliary-mediated ligation.

Graphical abstract: Orthogonal ligation: a three piece assembly of a PNA–peptide–PNA conjugate

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Article information

DOI
https://doi.org/10.1039/B801242C
Article type
Communication
Submitted
23 Jan 2008
Accepted
17 Mar 2008
First published
14 Apr 2008

Chem. Commun., 2008, 2785-2787

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Orthogonal ligation: a three piece assembly of a PNA–peptide–PNA conjugate

F. Burlina, D. D. Dixson, R. P. Doyle, G. Chassaing, C. N. Boddy, P. Dawson and J. Offer, Chem. Commun., 2008, 2785 DOI: 10.1039/B801242C

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