Issue 8, 2007
From the journal:

Chemical Society Reviews

The growing applications of click chemistry

John E. Mosesa  and  Adam D. Moorhousea  

a Department of Pharmaceutical & Biological Chemistry, The School of Pharmacy, University of London, 29-39 Brunswick Square, London, UK
E-mail: john.moses@pharmacy.ac.uk
Fax: + (0)20 7753 5964
Tel: + (0)20 7753 5804

Abstract

Click chemistry, the subject of this tutorial review, is a modular synthetic approach towards the assembly of new molecular entities. This powerful strategy relies mainly upon the construction of carbon–heteroatom bonds using spring-loaded reactants. Its growing number of applications are found in nearly all areas of modern chemistry from drug discovery to materials science. The copper(I)-catalysed 1,2,3-triazole forming reaction between azides and terminal alkynes has become the gold standard of click chemistry due to its reliability, specificity and biocompatibility.

Graphical abstract: The growing applications of click chemistry

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Article information

DOI
https://doi.org/10.1039/B613014N
Article type
Tutorial Review
Submitted
05 Apr 2007
First published
03 May 2007

Chem. Soc. Rev., 2007,36, 1249-1262

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The growing applications of click chemistry

J. E. Moses and A. D. Moorhouse, Chem. Soc. Rev., 2007, 36, 1249 DOI: 10.1039/B613014N

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