Issue 40, 2006
From the journal:

Chemical Communications

Total synthesis of antillatoxin†

Kiew-Ching Leea  and  Teck-Peng Loh*a  

* Corresponding authors

a Division of Chemistry and Biological Chemistry, Nanyang Technological University, Singapore
E-mail: teckpeng@ntu.edu.sg
Fax: +65 6791 1961
Tel: +65 6316 8899

Abstract

The total synthesis of natural (4R,5R)-antillatoxin and its analog (4S,5S)-antillatoxin has been achieved; the optically pure key intermediates were prepared from indium mediated allylation of either primary or secondary allylic bromide with aldehyde in aquoues media, followed by highly selective Luche's reduction and chiral resolution.

Graphical abstract: Total synthesis of antillatoxin

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Article information

DOI
https://doi.org/10.1039/B608193M
Article type
Communication
Submitted
08 Jun 2006
Accepted
07 Aug 2006
First published
24 Aug 2006

Chem. Commun., 2006, 4209-4211

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Total synthesis of antillatoxin

K. Lee and T. Loh, Chem. Commun., 2006, 4209 DOI: 10.1039/B608193M

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