Issue 36, 2005
From the journal:

Chemical Communications

Highly cytotoxic iron(ii) complexes with pentadentate pyridylligands as a new class of anti-tumor agents†

Ella Lai-Ming Wong,a   Guo-Su Fang,a   Chi-Ming Che*a  and  Nianyong Zhua  

* Corresponding authors

a Department of Chemistry and Open Laboratory of Chemical Biology of the Institute of Molecular Technology for Drug Discovery and Synthesis, The University of Hong Kong, Pokfulam Road, Hong Kong
E-mail: cmche@hku.hk
Fax: +(852)-2857-1586

Abstract

The iron(II) complexes 1a and 2 with pentadentate pyridyl ligands are stable under physiological conditions and exhibit higher cytotoxicities toward a series of human carcinoma cell lines than cisplatin; 1a can significantly increase intracellular oxidant levels, cleave supercoiled plasmid DNA in vitro without addition of a reductant and induce apoptotic cell death in human cervical epithelioid carcinoma cells (HeLa) as observed in flow cytometric studies.

Graphical abstract: Highly cytotoxic iron(ii) complexes with pentadentate pyridyl ligands as a new class of anti-tumor agents

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Article information

DOI
https://doi.org/10.1039/B507687K
Article type
Communication
Submitted
01 Jun 2005
Accepted
15 Jul 2005
First published
19 Aug 2005

Chem. Commun., 2005, 4578-4580

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Highly cytotoxic iron(II) complexes with pentadentate pyridyl ligands as a new class of anti-tumor agents

E. L. Wong, G. Fang, C. Che and N. Zhu, Chem. Commun., 2005, 4578 DOI: 10.1039/B507687K

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