Issue 10, 2005
From the journal:

Chemical Communications

Supramolecular assemblies of DNA with neutral nucleoside amphiphiles†

Philippe Barthelemy,a   Carla A. H. Prata,b   Shaun F. Filocamo,b   Chad E. Immoos,d   Benjamin W. Maynor,e   S. A. Nadeem Hashmi,f   Stephen J. Leec  and  Mark W. Grinstaff*b  

* Corresponding authors

a Faculté des sciences d'Avignon, 33 rue Louis Pasteur, Avignon, France

b Departments of Chemistry and Biomedical Engineering, Boston University, Boston, MA 02215, USA
E-mail: mgrin@bu.edu
Fax: +1-617-353-6466
Tel: +1-617-358-3429

c Army Research Office, RTP, NC 27709, USA

d Department of Chemistry, California Polytechnic State University, San Luis Obispo, CA 93407, USA

e Department of Chemistry, University of North Carolina at Chapel Hill, NC 27599, USA

f Department of Chemistry, Duke University, Durham, NC 27708, USA

Abstract

A neutral uridine-based amphiphile is described which condenses plasmid DNA. AFM studies show that the three distinct structural components of the amphiphile (i.e, nucleobase, alkyl chains, and poly(ethylene glycol)) are required for the formation of DNA–amphiphile supramolecular assemblies on a mica surface.

Graphical abstract: Supramolecular assemblies of DNA with neutral nucleoside amphiphiles

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Article information

DOI
https://doi.org/10.1039/B412670J
Article type
Communication
Submitted
17 Aug 2004
Accepted
17 Dec 2004
First published
21 Jan 2005

Chem. Commun., 2005, 1261-1263

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Supramolecular assemblies of DNA with neutral nucleoside amphiphiles

P. Barthelemy, C. A. H. Prata, S. F. Filocamo, C. E. Immoos, B. W. Maynor, S. A. N. Hashmi, S. J. Lee and M. W. Grinstaff, Chem. Commun., 2005, 1261 DOI: 10.1039/B412670J

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