Issue 17, 2004
From the journal:

Organic & Biomolecular Chemistry

Biosynthesis of cervimycin C, an aromatic polyketide antibiotic bearing an unusual dimethylmalonyl moiety

Kerstin Herold,a   Zhongli Xu,a   Friedrich A. Gollmick,a   Udo Gräfe†a  and  Christian Hertweck*a  

* Corresponding authors

a Depts. Biostructure Chemistry and Bioorganic Synthesis, Hans-Knöll-Institute for Natural Products Research, Beutenbergstr. 11a, Jena, Germany
E-mail: christian.hertweck@hki-jena.de
Fax: INT+3641-656705
Tel: INT+3641-656700

Abstract

Cervimycin C is the major component of an antibiotic complex produced by Streptomyces tendae HKI-179 consisting of a tetracycline-type aglycon, six tridesoxysugars and a rare dimethylmalonyl moiety. The biosynthetic origin of cervimycin was studied by molecular studies and feeding experiments, which reveal that the dimethylmalonate unit is not derived from malonate, but from valine.

Graphical abstract: Biosynthesis of cervimycin C, an aromatic polyketide antibiotic bearing an unusual dimethylmalonyl moiety

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Article information

DOI
https://doi.org/10.1039/B409221J
Article type
Communication
Submitted
17 Jun 2004
Accepted
19 Jul 2004
First published
04 Aug 2004

Org. Biomol. Chem., 2004,2, 2411-2414

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Biosynthesis of cervimycin C, an aromatic polyketide antibiotic bearing an unusual dimethylmalonyl moiety

K. Herold, Z. Xu, F. A. Gollmick, U. Gräfe and C. Hertweck, Org. Biomol. Chem., 2004, 2, 2411 DOI: 10.1039/B409221J

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