Issue 15, 2003
From the journal:

Chemical Communications

First enzymatic synthesis of an N1-cyclised cADPR (cyclic-ADP ribose) analogue with a hypoxanthine partial structure: discovery of a membrane permeant cADPR agonist

Gerd K. Wagner,a   Steven Black,a   Andreas H. Guseb  and  Barry V. L. Potter*a  

* Corresponding authors

a University of Bath, Department of Pharmacy and Pharmacology, Wolfson Laboratory of Medicinal Chemistry, Claverton Down, Bath, UK
E-mail: prsbvlp@bath.ac.uk
Fax: ++44-1225-386114
Tel: ++44-1225-386639

b University Hospital Hamburg-Eppendorf, Institute of Medical Biochemistry and Molecular Biology I: Cellular Signal Transduction, Martinistr. 52, D-20246 Hamburg, Germany
E-mail: guse@uke.uni-hamburg.de
Fax: ++49-40-42803-9880
Tel: ++49-40-42803-2828

Abstract

Nicotinamide 8-Br-hypoxanthine dinucleotide (8-Br-NHD+) was cyclised at the N1 position by the ADP-ribosyl cyclase from Aplysia californica to give cyclic 8-Br-inosine diphosphoribose (8-Br-N1-cIDPR), a novel membrane-permeant agonist of Ca2+ release in human T cells.

Graphical abstract: First enzymatic synthesis of an N1-cyclised cADPR (cyclic-ADP ribose) analogue with a hypoxanthine partial structure: discovery of a membrane permeant cADPR agonist

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Article information

DOI
https://doi.org/10.1039/B305660K
Article type
Communication
Submitted
22 May 2003
Accepted
18 Jun 2003
First published
01 Jul 2003

Chem. Commun., 2003, 1944-1945

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First enzymatic synthesis of an N1-cyclised cADPR (cyclic-ADP ribose) analogue with a hypoxanthine partial structure: discovery of a membrane permeant cADPR agonist

G. K. Wagner, S. Black, A. H. Guse and B. V. L. Potter, Chem. Commun., 2003, 1944 DOI: 10.1039/B305660K

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