Issue 21, 2002
From the journal:

Chemical Communications

PEG-Linked luminescent platinum(ii) complex as aqueous polymeric molecular light switch for protein binding reactions†

Chi-Ming Che,*a   Jun-Long Zhanga  and  Li-Rong Lina  

* Corresponding authors

a Department of Chemistry and Open Laboratory of Chemical Biology of the Institute of Molecular Technology for Drug Discovery and Synthesis, The University of Hong Kong, Pokfulam Road, Hong Kong
E-mail: cmche@hku.hk
Fax: (852)2857-1586

Abstract

Attachment of poly(ethylene glycol) (PEG) to [Pt(4-HOPh-C⁁N⁁N)Cl] via covalent etheric bonds yields the luminescent polymer PEG-[Pt] (2), the photoluminescence of which is enhanced in hydrophobic regions of protein molecules (binding constant up to 104 M−1) in aqueous solution; complex 2 can function as a luminescent probe for protein denaturation due to urea unfolding reaction.

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Article information

DOI
https://doi.org/10.1039/B207395A
Article type
Communication
Submitted
29 Jul 2002
Accepted
18 Sep 2002
First published
02 Oct 2002

Chem. Commun., 2002, 2556-2557

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PEG-Linked luminescent platinum(II) complex as aqueous polymeric molecular light switch for protein binding reactions

C. Che, J. Zhang and L. Lin, Chem. Commun., 2002, 2556 DOI: 10.1039/B207395A

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