Issue 23, 2001
From the journal:

Chemical Communications

A surprisingly mild and versatile method for palladium-catalyzed Suzuki cross-couplings of aryl chlorides in the presence of a triarylphosphine†

Shih-Yuan Liu,a   Michael J. Choia  and  Gregory C. Fu*a  

* Corresponding authors

a Department of Chemistry, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA.
E-mail: gcf@mit.edu

Abstract

In the presence of new air-stable triarylphosphine 2, palladium-catalyzed Suzuki reactions of a wide array of aryl chlorides can be accomplished in uniformly good yield, including couplings of very sterically demanding and electronically deactivated substrates; activated aryl chlorides can be coupled at room temperature. In terms of scope and mildness, Pd–2 compares well with other catalyst systems that have been described for Suzuki reactions of aryl chlorides, thereby establishing that triarylphosphines should be regarded as fertile ground for future ligand-design efforts for palladium-catalyzed couplings of aryl chlorides.

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Article information

DOI
https://doi.org/10.1039/B107888G
Article type
Communication
Submitted
30 Aug 2001
Accepted
21 Sep 2001
First published
08 Nov 2001

Chem. Commun., 2001, 2408-2409

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A surprisingly mild and versatile method for palladium-catalyzed Suzuki cross-couplings of aryl chlorides in the presence of a triarylphosphine

S. Liu, M. J. Choi and G. C. Fu, Chem. Commun., 2001, 2408 DOI: 10.1039/B107888G

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