Comparison of mercury- and glassy carbon-based electrochemical detection systems for the determination of cisplatin following high-performance liquid chromatographic separation
Abstract
A comparison has been made between the use of mercury- and glassy carbon-based electrodes as electrochemical detection systems for the determination of cisplatin and its hydrolysis products, in addition to chloride, following high-performance liquid chromatographic separation. Separation was achieved using ion-pair chromatography, employing octanesulphonic acid as a modifier. Limits of detection of approximately 5 µg ml–1 and 370 ng ml–1 of cisplatin were obtained using a hanging mercury drop electrode and a single glassy carbon electrode, respectively. When a dual glassy carbon electrode operated in a parallel orientation was employed the detection limit was decreased to 25 ng ml–1 of cisplatin.
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